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Adjuvant Trial in Patients With Resected PDAC Randomized to Allocation of Oxaliplatin- or Gemcitabine-based Chemotherapy by Standard Clinical Criteria or by a Transcriptomic Treatment Specific Stratification Signature

Trial for PDAC patients testing different chemotherapy methods.

Recruiting
18-79 years
All
Phase 3

This study is for people with a type of pancreatic cancer called **pancreatic ductal adenocarcinoma (PDAC)**. The study tests two chemotherapy treatments: oxaliplatin and gemcitabine. These are medicines that help slow down or stop cancer growth. The study aims to see if using a special method called the **Transcriptomic Treatment Specific Stratification Signature (TSS)** to decide which treatment is better than using regular methods.

Researchers also want to understand how well people live without cancer coming back and how long they live overall. They will collect samples to learn more about how the body responds to the treatments. This could help create better treatments in the future.

  • **Duration**: The study lasts several months with regular hospital visits.
  • **Requirements**: Participants must be between 18-79 years old, have had surgery for PDAC, and be able to handle chemotherapy.
  • **Risks**: As in any study, there may be side effects. Talk to your doctor to understand them.
Study details
    Pancreatic Ductal Adenocarcinoma

NCT05314998

John Neoptolemos

5 September 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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