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TCR1188-ABC Cells in KRAS-mutated Cancers

Participate in a study for a new treatment in KRAS-mutated cancers.

Recruiting
18 years and older
All
Phase 1

This study is testing the safety of a new treatment called TCR1188-ABC cells for certain cancers with a KRAS mutation, which is a change in the DNA of cancer cells. It includes cancers like pancreatic, colorectal, cholangiocarcinoma, and non-small cell lung cancer. This study will help find out how much of the treatment can be given safely and if it works on these cancers.

**Key Points to Consider:**

  • **Study Length & Visits:** The study involves multiple visits for treatment and monitoring.
  • **Eligibility:** Only adults with specific cancer types and genetic changes can join.
  • **Risks:** Possible side effects and risks will be explained by the study doctors.

To join, patients must have already tried some standard treatments for their cancer. They also need to be in good health overall, with working organs and no serious infections or other cancers. People with certain health issues like heart problems or active infections cannot join. Participants must agree to use birth control if they can have children.

Study details
    Cholangiocarcinoma
    Colorectal Cancer
    Non-Small Cell Lung Cancer
    Pancreatic Adenocarcinoma

NCT07594067

University of Pennsylvania

17 October 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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