Study Overview: This study explores a new way to treat pancreatic neoplasms (tumors). A neoplasm is an abnormal growth of tissue, which can be cancerous. The study uses a method called endoscopic ultrasound-guided pulsed electric field ablation (EUS-PEF). This is a minimally invasive technique that uses electric pulses to destroy tumor cells without harming nearby healthy tissue.

Method: The procedure involves inserting a thin needle into the body with the help of an endoscope (a thin tube with a camera) to deliver electric pulses directly to the tumor. This process aims to treat precancerous or high-risk pancreatic cysts without surgery.

Key Points:

• Participants will undergo the EUS-PEF procedure on day 0 and follow-up visits at 3 and 6 months, then annually for 3 years.
• Eligible participants must be over 18, diagnosed with a pancreatic neoplasm, and not suitable for surgery due to other health issues.
• Women of childbearing age must test negative for pregnancy before treatment.

This study aims to ensure the safety and success of this new treatment option, potentially offering a less risky alternative to surgery for some patients.