Progressive Supranuclear Palsy (PSP) is a brain disorder that causes serious problems with walking, balance, and eye movements. This study is testing if a new medicine called NIO752 can help people with this condition. Participants will be chosen by chance to receive either NIO752 or a placebo (a pill that does nothing) for a period of time. After this initial period, everyone will get the chance to take NIO752 in an open-label extension, meaning everyone knows they are getting the real medicine.

Key Points:

• The study may last several months, and participants must visit the study site multiple times.
• Participants need to have a study partner who can help with visits and provide information.
• Participants must be able to walk at least 10 steps with or without minimal help.

To join, you must be between 41 and 81 years old, have a probable diagnosis of mild to moderate PSP, and not have other serious brain or mental disorders. Safety checks like MRI scans and memory tests will be done to see if you qualify. If you’re interested, getting informed consent is necessary before starting.