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Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS

Exploring how exercise helps Parkinson's patients with brain implants.

Recruiting
18 years and older
All
Phase 2

This study is for people with Parkinson's disease (PD) who have a device called Deep Brain Stimulation (DBS) to help with their symptoms. Parkinson's disease is a condition that affects your movement and thinking. The study wants to see how two types of biking exercise, called forced exercise (FE) and voluntary exercise (VE), help people with PD. Forced exercise uses a motor to help you pedal faster, while voluntary exercise lets you pedal at your own pace.

Over 8 weeks, 36 participants will either do forced or voluntary cycling. The study will measure how well people move, think, and how their brain works. It will use EEG (a test that checks brain activity) and the DBS device to get information about the brain.

To be part of the study, you need to be able to walk for 5 minutes with or without help and be willing to pause your PD medication and DBS for testing. You cannot join if you have other brain diseases or certain health issues.

  • Study lasts 8 weeks with exercises and a delayed start period.
  • Participants must have a DBS device and be able to walk for 5 minutes.
  • Medical clearance might be needed for some participants.
Study details
    Parkinson's Disease
    Deep Brain Stimulation

NCT07442747

The Cleveland Clinic

2 August 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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