Sickle cell disease (SCD) is a condition affecting red blood cells, making it hard for them to carry oxygen. This study tests a skin gel called VAS-101, containing curcumin from turmeric, which might help these cells. Curcumin usually doesn't get absorbed well in the body when taken by mouth, but VAS-101 could improve this.
People aged 18 to 70 with stable SCD can join. Participants will apply VAS-101 gel on their forearms twice a week for 6 weeks. The study includes up to 15 clinic visits over 14 weeks. Some visits involve blood tests and a special test called near-infrared spectroscopy (NIRS), which checks blood flow and oxygen levels.
- Participants will have up to 15 clinic visits over approximately 14 weeks.
- Compensation may be provided for participation.
- Participants may need to stay overnight in the hospital for up to 2 days during the study.
The study aims to see if VAS-101 is safe and helps red blood cells in SCD patients. Participants should not take other turmeric or curcumin products during the study.