This study looks at a new medicine called BMS-986470 for people with Sickle Cell Disease (SCD) and healthy volunteers. SCD is a condition where red blood cells, which usually carry oxygen, become sickle-shaped and can block blood flow. The study will check if the medicine is safe and how it affects the body. It will also explore how food and the body's natural acidity (pH) affect the medicine.

Eligibility: Healthy people and those with SCD can join. You must be healthy or have SCD as described, and cannot have certain other medical problems.

Key Points:

• The study involves different groups: one with healthy people and another with those having SCD.
• Participants need to meet specific health criteria, including age, body mass index (BMI), and blood test results.
• Exclusions include recent surgeries, certain medical conditions, and recent blood transfusions.