This study is about a new medicine called PF-08634404 for people with non-small cell lung cancer (NSCLC), which is a type of lung cancer. It can be early-stage (Stage II) or locally advanced (Stage III), meaning it may not have spread far. The study is looking at how well this medicine works alone or with chemotherapy, which is a type of medicine to kill cancer cells. Participants need to be 18 or older and in good health. They should not have any known changes in their DNA that could affect the study.

• The study has 3 parts, and your doctor will decide which part is right for you.
• All treatments and check-ups will be done at special research sites with a medical team watching over you.
• Participants should not have severe allergies or other major health issues.