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Decoding the Neural Mechanisms Underlying Postural Instability and Gait Dysfunction in Parkinson's Disease

Studying balance and walking issues in Parkinson's disease.

Recruiting
18 years and older
All
Phase N/A

This research aims to understand how brain signals affect walking and balance issues in Parkinson's disease (PD) patients. PD is a disease that gets worse over time and affects movement, like causing shaking or stiffness. Even with treatments like deep brain stimulation (DBS), people still face problems like losing balance or "freezing" while walking. This study explores how different DBS settings might help.

Participants will do walking and balance tasks in virtual reality, which creates real-life situations that can trigger these issues. The study records brain signals and motion to see how they relate to walking troubles. This may help create better treatments in the future.

  • Eligibility: Only for PD patients with a specific DBS device.
  • Tests: Multiple sessions with different DBS settings and virtual reality tasks.
  • Risks: May involve stopping some medications temporarily.
Study details
    Parkinson Disease
    Freezing of Gait

NCT07748962

The Cleveland Clinic

1 November 2026

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