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A Trial to Evaluate the Safety and Tolerability of DV700P-RNA and DV701B1.1-RNA Immunization in Combination With Antiretroviral Analytical Treatment Interruption (ATI) in People Living With HIV for Elicitation of V3-glycan Antibodies

Testing safety of new HIV vaccine combined with temporary medication pause.

Recruiting
18-60 years
All
Phase 1

This study is testing two new vaccines for HIV, the virus that causes AIDS, in adults who already have HIV. The vaccines use a type of genetic material called mRNA (messenger Ribonucleic Acid) to help the body make antibodies, which are proteins that help fight infections. Participants will stop taking their regular HIV medicines for a short time, under careful watch, to see if the vaccines can still help protect them. About 42 people will join the study, which is a Phase 1 trial - the first step in testing new treatments to make sure they are safe and well-tolerated. Participants need to be in good health and have their HIV well-controlled with current treatments.

  • Participants will need to stop their regular HIV medications temporarily during the study.
  • Participants must agree to use condoms and not become pregnant during the study.
  • The study will include multiple visits to the study center for monitoring and tests.
Study details
    HIV

NCT07569029

National Institute of Allergy and Infectious Diseases (NIAID)

17 October 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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