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Investigating the Impact of GLP-1 RA Therapy on Osteosarcopenia in Older Female Adults With Diabetes

Studying diabetes medication effects on bone and muscle health in older women.

Recruiting
65 years and older
Female
Phase 3

This study is for older women over 65 with type 2 diabetes. The main goal is to see if a medication called **GLP-1 RA** (Glucagon-like peptide-1 receptor agonist) affects muscle and bone health. **Osteosarcopenia** is when muscles and bones get weaker, which can lead to falls and fractures. This is a big concern for older women with diabetes.

Participants will be on GLP-1 RA therapy, which is already part of their regular care. During the study, they will have tests to check muscle strength, like a hand grip test, and bone health through blood tests and bone density scans. The study lasts 6 months, and participants won't have to change their usual treatment plans.

The study will help understand if GLP-1 RA therapy affects muscle strength and bone health in these women. This knowledge will help doctors support women with diabetes better in the future.

  • Study lasts 6 months with routine and special tests.
  • Participants receive GLP-1 RA therapy as usual care.
  • No alteration in their current treatment; focus is on observation.
Study details
    Diabetes Mellitus
    Type 2

NCT07428746

Emory University

17 October 2026

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