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Safinamide vs Placebo for Pain in Patients With Parkinson's Disease and Motor Fluctuations

Study on Safinamide for Parkinson's pain and movement changes.

Recruiting
18 years and older
All
Phase 3
This trial is testing a new medicine called **safinamide** to see if it helps with pain for people with Parkinson's Disease (PD). PD is a brain disorder that affects movement and can cause pain. Safinamide will be compared to a **placebo**, which is a fake treatment with no medicine in it. This study wants to see if safinamide can reduce pain better than the placebo. - **Study Length**: The treatment lasts for 12 weeks, and the whole study will take 24 months to complete. - **Visits**: Participants will take safinamide or placebo daily, with doses increasing after the first week. - **Risks and Benefits**: Possible benefits include pain relief, but there may be risks like drug side effects. Participants must be at least 18, have had PD for 3 years, and experience motor issues and pain despite taking levodopa, a common PD medication. Women in the study must take a pregnancy test and use birth control. Some people, such as those with certain other illnesses or using certain drugs, cannot join the study.
Study details
    PARKINSON DISEASE (Disorder)
    Pain
    Pain Management
    Parkinson Disease (PD)

NCT07761936

Universita di Verona

22 August 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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