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A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence

Testing Cleminorexton for sleep disorders compared to a placebo.

Recruiting
18-70 years
All
Phase 2/3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is about a new medicine called Cleminorexton, which is being tested to help people with Narcolepsy Type 1 (NT1) and Narcolepsy Type 2 (NT2). These are conditions that make people feel very sleepy during the day. NT1 can also cause cataplexy, a sudden loss of muscle strength. Cleminorexton is designed to act like orexin, a brain protein that helps keep people awake.

Key Points:

  • Participants must be between 18-70 years old and willing to stop other narcolepsy medications during the study.
  • The study checks for safety and effects of Cleminorexton on NT1 and NT2 symptoms.
  • People with other illnesses causing daytime sleepiness or significant health problems can't join.
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Study details
    Narcolepsy Type 1
    Narcolepsy Type 2

NCT07598708

Centessa Pharmaceuticals (UK) Limited

17 October 2026

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