This study aims to find out how well a new treatment called AXS-05 helps adults stop smoking. It compares AXS-05 to a placebo (a pill that looks like the real medicine but has no active ingredients) and another medicine called bupropion, which is already used to help people quit smoking. The study is Phase 3, meaning it is in the later stages of testing, and it involves many participants across different locations. Participants will be randomly assigned to receive either AXS-05, bupropion, or placebo for 12 weeks, and will be followed for an additional 18 weeks after treatment. To join, you must be between the ages of 18 and 65 and able to follow the study rules. You cannot join if the study doctor thinks it's not safe for you.

• The study lasts for about 30 weeks in total.
• Participants will visit the study site for check-ups and monitoring.
• There may be risks or side effects, similar to other medicines.