This study looks at finding genetic reasons for parkinsonism, a condition causing movement problems similar to Parkinson's disease. Researchers will use a method called genome and RNA sequencing to study 14 patients with early-onset parkinsonism, which means symptoms started before age 40. Genome sequencing is a process that reads all of a person’s DNA, while RNA sequencing examines RNA, molecules that help make proteins in cells. They want to discover new genetic causes by analyzing both the patients' DNA and RNA. Researchers will take blood and skin samples from the patients and their family members to do this. Skin samples are used because genes important for brain diseases are often active in the skin too. They will use special machines to read the genetic material and advanced software to find any unusual patterns or changes. This study might help in better understanding and treating parkinsonism.

• Commitment: Blood and skin sample collection is needed.
• Participants: 14 patients with early-onset parkinsonism.
• Analysis: Genome and RNA sequencing will be performed.