**Study Overview**: This study is looking at the safety and effects of a new vaccine called TRB-001. It's designed for people who have already tried a treatment for Parkinson's disease called aSyn immunotherapy. Parkinson's disease is a brain disorder that affects movement. **Who Can Join?**: To participate, you must be at least 18 and have been treated with aSyn immunotherapy. You must also have Parkinson's disease. **Exclusions**: You cannot join if you have certain health issues like autoimmune diseases, active infections (like hepatitis or HIV), or if you are pregnant. People with severe mental health issues or recent cancer history are also excluded. **Key Points**: - **Study Visits**: Participants will need to visit the study site for check-ups and tests. - **Compensation**: There may be compensation for time and travel. - **Risks**: There could be side effects from the vaccine, and some people may not be eligible due to health conditions. This is a pilot study, meaning it's an early test to see how the vaccine works and if it's safe. Participants will be closely monitored.

It is important to talk to your doctor to see if this study is right for you.