This study is for young people with Sickle Cell Disease (SCD), a blood disorder that causes pain and affects daily life. The trial will check if music therapy (MT) can help reduce pain and improve mood over a 4-week period. Music therapy is a safe way to manage pain without using medicine. It uses a special program called Music Care© that plays music to help relax and reduce stress.

Researchers will also look at how MT affects the body on a molecular level by studying immune cells. This involves a test called single-cell RNA sequencing (scRNA-seq) that looks at tiny details in cells. They will compare results with a control group to see if MT shows better outcomes.

• The study lasts 4 weeks and involves using a virtual music platform.
• Participants must have SCD, speak English, and access the internet.
• People with major hearing issues or conditions worsened by music cannot join.