Study Goal: This study looks at how fast we can find the right dose of a medicine called hydroxyurea (HU) for kids with sickle cell anemia. Sickle cell anemia is a condition where red blood cells are shaped like a sickle, which can cause pain and other problems. Hydroxyurea helps make the red blood cells rounder. We'll try two ways to adjust the medicine dose: one using special tests called pharmacokinetic tests to see how the body handles the medicine, and the other using regular blood tests.
Who Can Join?: Kids between 6 months and 18 years old with a confirmed diagnosis of sickle cell disease (SCD) and certain types of SCD (SS, SBThal0) can join. They must agree to take HU for 12 months for Groups A and B or have already been on HU for 12 months for Group C.
- The study lasts for 12 months.
- Participants will be divided into groups by chance (like a coin toss).
- Participants must visit the hospital for tests and follow-ups.