Sickle Cell Disease (SCD) is a blood disorder that can cause chronic pain and emotional issues. This study wants to see if music therapy (MT), a treatment using music, can help young people with SCD feel less pain and improve their mood and daily life. The therapy lasts for 4 weeks and uses a special music program called Music Care©, which starts with lively music and ends with calm music.

Researchers will also look at how MT changes immune cells (cells that help fight sickness) using a process called single-cell RNA sequencing (scRNA-seq). This will help scientists understand how MT affects the body at a cellular level. To join the study, participants must have SCD, understand English, have a device like a phone or tablet with internet access, and have had pain for at least 3 months.

• Study lasts 4 weeks with music therapy sessions.
• Participants must have access to a device with internet.
• Music therapy could improve pain and mood without medication.