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A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung Cancer

Study of VS-7375 for specific lung cancer mutation.

Recruiting
18 years and older
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Phase 2

This study is testing a new treatment, VS-7375, for patients with a type of lung cancer called KRAS G12D-mutated Non-Small Cell Lung Cancer (NSCLC). This cancer type has a specific gene change called a mutation. The study will check how safe and effective VS-7375 is alone, and when combined with a drug called cetuximab.

Eligibility: Patients need to have advanced lung cancer that cannot be removed by surgery (unresectable) and have already tried treatments like chemotherapy and immune therapy. They should have a specific mutation in the KRAS gene and good organ function. Patients must have disease that can be measured using a special method called RECIST 1.1.

  • The study may involve multiple visits to the clinic for check-ups and treatments.
  • Patients must not have had certain other treatments or surgeries close to the study start.
  • It’s important to discuss potential risks and benefits with your doctor.

Consider joining if you meet the criteria and are looking for new treatment options.

Study details
    Non-Small Cell Lung Cancer

NCT07659782

Verastem, Inc.

17 October 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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