This study aims to explore the safety and effectiveness of a new medicine for chronic low back pain (CLBP). Pain is considered chronic if it lasts for more than three months. CLBP is pain located between the lower back and lower buttocks. The study is part of a larger project called the chronic pain master protocol, which helps speed up finding new treatments for chronic pain.

Eligibility:

• Participants must have had low back pain for at least three months.
• Participants should have a body mass index (BMI) of 40 or less. BMI measures body fat based on height and weight.
• Participants must have controlled blood sugar levels, shown by a glycated hemoglobin (HbA1c) of 10 or less.
• Participants cannot be pregnant or breastfeeding.

Key Points:

• The study will assess a new treatment for chronic low back pain.
• Participants will undergo health checks to ensure they meet health criteria.
• Exclusions include recent spinal injections or major spinal deformities.