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A Study to Assess Adverse Events and Change in Disease Activity When Intravenous (IV) Pivekimab Sunirine is Given in Combination With Oral Venetoclax and IV or Subcutaneous Azacitidine in Adult Participants With Acute Myeloid Leukemia (AML)

Testing a new combination of medications for Acute Myeloid Leukemia (AML).

Recruiting
18 years and older
All
Phase 2/3
  • Simplified description (AI rewritten)
  • Technical description (Original)

Acute Myeloid Leukemia (AML) is a type of cancer that affects blood and bone marrow, making it hard for the body to produce normal blood cells. This study looks at the effects of a drug called Pivekimab Sunirine (PVEK) when used with other medicines, Venetoclax (VEN) and Azacitidine (AZA), in adults with AML who can't have strong chemotherapy. Pivekimab Sunirine is given through a vein, Azacitidine can be given through a vein or under the skin, and Venetoclax is a pill. The study lasts about 71 months and is done at 180 locations worldwide.

  • This study involves regular hospital or clinic visits for check-ups and tests.
  • Participants may face higher treatment demands compared to usual care.
  • Approximately 660 adults will take part in this study across 180 sites globally.
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Study details
    Acute Myeloid Leukemia

NCT07581002

AbbVie

11 October 2026

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