**This study** aims to explore a treatment for **locally advanced pancreatic cancer**, a type of cancer that cannot be removed by surgery. This study involves two groups: one group will receive a treatment called **IRE (Irreversible Electroporation)** after three rounds of chemotherapy, while the other group will continue with chemotherapy only. **IRE** is a treatment that uses electricity to destroy cancer cells without harming the surrounding tissue. The study will look at how well patients respond to the treatments, their overall survival (OS), and progression-free survival (PFS), which means how long the cancer stays under control. It will also check the quality of life (QoL) and safety of the treatments. - **Key Points to Consider:** - The study involves about 60 patients randomly assigned to one of the treatment groups. - Patients will be monitored for several outcomes, including tumor response and safety. - Participation requires a commitment to follow the treatment plan and attend follow-up visits. Patients must be between 18-75 years old, have confirmed pancreatic cancer, and meet other health criteria. Participants must not have cancer spread to other body parts or severe other health issues.