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Comparison of [68Ga]Ga-HBED-CC-PEG6-Exendin-4 and [68Ga]Ga-HBED-CC-Exendin-4 PET/CT for Insulinoma Localization

Study comparing two PET/CT scans for locating insulinomas.

Recruiting
18-70 years
All
Phase N/A

This study is testing a new imaging agent to find insulinoma, a rare tumor in the pancreas that causes low blood sugar. Traditional scans often miss these tiny tumors. The new agent, called **[68Ga]Ga-HBED-CC-PEG6-Exendin-4**, is designed to better detect insulinomas by targeting a protein called GLP1R, which is found in high amounts on these tumors.

Twenty adults with suspected insulinoma will join the study. Participants will get two free PET/CT scans in one week with two different tracers: one new and one old. The scans are safe and have low radiation. Within a month of the scans, participants will have surgery or a biopsy to confirm the tumor's presence and compare scan results. Participants won't pay for the scans and will receive a report for their doctor.

  • Duration: Two scans within one week; surgery or biopsy within one month.
  • Risks: Minor pain or allergic reactions; rare effects from Exendin-4.
  • Benefits: Improved tumor detection to aid treatment planning.
Study details
    Insulinoma

NCT07808879

Peking Union Medical College Hospital

12 September 2026

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