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A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)

Study on Letermovir for young kidney transplant patients.

Recruiting
17 years and younger
All
Phase 1

Researchers are studying a medicine called letermovir to help prevent a virus called cytomegalovirus (CMV) in kids who have had a kidney transplant and weigh less than 88.2 pounds. A kidney transplant means a person gets a new kidney from another person. CMV is a virus that can make you sick, especially if you've had a transplant. This study will check how letermovir moves through the body and see if it is safe for kids.

To join the study, participants must have had their kidney transplant 4 to 52 weeks ago, cannot have CMV, and must not be on dialysis (a machine that cleans the blood). They should also weigh at least 5.5 pounds.

  • This study may last several weeks, with visits needed to check how the medicine is working.
  • Participants must be able to take medicine by mouth or through a tube.
  • The study will check if the medicine is safe and how it affects the body.
Study details
    Cytomegalovirus Prophylaxis

NCT07199465

Merck Sharp & Dohme LLC

17 October 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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