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A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)

A study comparing Divarasib to other treatments for KRAS G12C lung cancer.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is testing a new medicine, divarasib, for people with a type of lung cancer called *KRAS G12C-positive non-small cell lung cancer (NSCLC)*. KRAS G12C is a change in a gene that can affect cancer growth. NSCLC is a common type of lung cancer. The study will compare divarasib with other treatments like immunotherapy (using medicines like pembrolizumab or nivolumab) or just watching to see how well patients do. To join, you must have had surgery to remove the cancer and had treatment with both chemo and immune medicines before surgery. You can't join if the cancer has come back or spread, or if you've had certain treatments before.

  • Duration: Participants must join within 12 weeks of surgery.
  • Eligibility: Must have no cancer recurrence and have specific gene mutation.
  • Risks: Previous immune-related issues may exclude participation.
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Study details
    Non-small Cell Lung Cancer

NCT07541170

Hoffmann-La Roche

17 October 2026

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