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A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

Testing a new eye injection for age-related vision loss.

Recruiting
60 years and older
All
Phase 1/2

This study is exploring a new treatment for people with Geographic Atrophy (GA), a condition affecting vision, which is linked to Age-related Macular Degeneration (AMD). The study tests a one-time shot (injection) into the eye called SAR446597. It will last about 2 years, with follow-up for an additional 3 years. This means you’ll be in touch with doctors for 5 years total.

Key Points:

  • The study lasts for 5 years (2 years core phase, 3 years follow-up).
  • Participants will receive a single injection in the eye.
  • You must be 60 or older and have specific vision measurements to join.

Only people with GA due to AMD can join. You cannot take part if your eye condition is caused by something else, if you’ve had certain treatments before, or if you have other eye problems. This study aims to check if the injection is safe and if it helps improve or stabilize vision. Remember, joining a study is voluntary and you should discuss with your doctor if it’s right for you.

Study details
    Geographic Atrophy

NCT07215234

Sanofi

17 October 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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