This study will test a medicine called orforglipron to see if it helps people who are overweight avoid getting serious health problems like type 2 diabetes (high blood sugar), hypertension (high blood pressure), and dyslipidemia (unhealthy cholesterol levels). To join, you must have a waist-to-height ratio of 0.5 or more and at least one health issue related to being overweight, such as prediabetes (early stage of high blood sugar), prehypertension (early stage of high blood pressure), or predyslipidemia (early stage of cholesterol issues). You also need to have tried and failed to lose weight through diet and exercise.

• The study does not accept people who have certain conditions like diabetes or have taken weight-loss medicines recently.
• Participants cannot have had or plan to have surgery for weight loss.
• The study excludes individuals with unstable body weight or those with a history of severe overweight.