This study looks at whether a drug called mitapivat helps kids with a condition called thalassemia, a blood disorder where the body doesn't make enough healthy red blood cells. "Non-transfusion-dependent" means these kids don't need regular blood transfusions. *Mitapivat* is compared to a placebo, which is a fake treatment often used in studies to see if the real drug works better. Participants must be between 1 and 18 years old and weigh at least 7 kilograms. They should not have received more than 5 blood transfusions in the past 24 weeks or any transfusions in the last 8 weeks. Also, some medications and conditions like certain liver, kidney, or heart diseases can disqualify participation.
- Study Duration: Participants will be involved until the study is completed.
- Eligibility: Kids aged 1 to 18 with thalassemia not needing regular transfusions.
- Risks and Benefits: Possible side effects from the drug; potential improvement in anemia.
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