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A Study to Assess Adverse Events, Change in Disease Activity and Optimal Dose of Intravenous (IV) Telisotuzumab Adizutecan With IV Pembrolizumab for First-Line Treatment of Adult Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Testing safety, effects, and best dose of two medications for head and neck cancer.

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for people with a type of cancer called head and neck squamous cell carcinoma (HNSCC). It looks at how two drugs, telisotuzumab adizutecan and pembrolizumab, work together to treat this cancer. Telisotuzumab adizutecan is an experimental drug given through a vein (intravenously). Pembrolizumab is a known medicine for cancer. People with cancer that has come back or spread and haven't had other treatments for it can join. They must have a protein called c-Met in their tumors. Around 180 people will join from many places worldwide.

  • The study lasts 67 weeks, with visits to a hospital or clinic every 3 weeks.
  • You might get more tests and procedures than usual care.
  • Regular check-ups will include medical assessments, blood tests, and questionnaires.
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Study details
    Head and Neck Squamous Cell Carcinoma

NCT07744126

AbbVie

17 October 2026

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