**Virtual Reality for SCD VOC Study** This study tests if virtual reality (VR) helps reduce pain for adults with sickle cell disease (SCD) during a painful event called vaso-occlusive crisis (VOC). Up to 50 people will try different VR experiences using a headset while visiting an infusion center for pain treatment. **Key Points:** - **Duration:** Each VR session lasts 45 minutes, alongside regular medical care. - **Participation:** Participants will have two sessions within six months. - **Compensation and Risks:** VR might reduce pain, but some may feel uncomfortable using the headset. Participants will be divided to receive two out of three VR types: a simple video (sham 2D), a 3D VR experience where they can look around (passive immersive), or a 3D VR where they can interact with the environment (active immersive). The main goal is to see if VR can reduce pain in the first hour, with other factors like how easy and comfortable the VR is to use also being checked. This study aims to find out if VR could be a helpful tool for managing VOC pain without using more medicine.