Found 6,933 clinical trials
Neoadjuvant Umbrella Trial for Patients With Unresectable Stage III NSCLC Harboring Rare Mutations.
This umbrella trial directed by next generation sequencing (NGS) includes patients with treatment-naive unresectable stage III non-small-cell lung cancer (NSCLC). The aim of the umbrella study is to evaluate the efficacy of induction NGS-directed targeted therapies followed by surgery for stage III NSCLC patients whose tumor harbors a rare mutation.
Reducing Falls With Varenicline in Hypocholinergic Parkinson Disease
This trial aims to test whether one year of Varenicline, when compared to placebo, can reduce fall risk and show improvement in the ability to multitask while walking.Participants that are eligible after screening for the study will be randomized to receive Varenicline or placebo. Along with the study medication participants …
A Phase 1/2 Study of TRI-611 in ALK-Positive NSCLC
The goal of this clinical trial is to learn about the safety and recommended dose of TRI-611 when administered to adults with ALK-positive non-small cell lung cancer (NSCLC). The trial will also evaluate the antitumor activity of TRI-611 in adults with ALK-positive NSCLC.The study will be conducted in two parts. …
Lorlatinib Plus Local Consolidation Therapy In ALK Positive Advanced Non-Small Cell Lung Cancer
This is an open-label, multicenter, randomized phase 2 trial for patients with tyrosine kinase inhibitor-naïve ALKrearranged advanced NSCLC. Subjects are initially treated with lorlatinib for 12 weeks.
Parental Experiences with Healthcare Providers During the Diagnostic Process for Rett Syndrome
Did you have a long diagnostic journey to receive your child’s Rett syndrome diagnosis? How did you feel about the care you received from healthcare providers during this journey? We are looking to investigate the diagnostic process for Rett syndrome from parental perspectives and explore experiences with healthcare providers throughout …
Development of a Reliable, Valid, and Sensitive Outcome Measure in Rett Syndrome
The purpose of this study is to assess the reliability and validity of a clinician reported clinical outcome assessment, the revised-motor behavior assessment (R-MBA). Participants will undergo in-person clinical structured evaluations at VUMC. These clinical evaluations will be video-taped to enable scoring by a second rater to establish inter-rater reliability, …
Clinical Validation of At-Home Methods of Sleep Assessment in Rett Syndrome
There are two parts to this study. First, we want to determine the reliability of a wearable device for sleep quality in RTT against the gold-standard polysomnography. Additionally, we want to determine whether sleep quality measured by the E4 device serves as a valid construct for sleep measurement and is …
The Canadian Open Parkinson Network
Currently, there is no disease modifying treatment for people with Parkinson’s and this kind of breakthrough will only happen if the Parkinson’s research community works together. The Canadian Open Parkinson Network (also known as C-OPN) was created to tackle this problem. It is a Canada-wide research network that bridges researchers, …
Expanded Access Program of Neladalkib (NVL-655) for Patients With Advanced ALK+ NSCLC or Other ALK+ Solid Tumors
The Expanded Access Program will provide an alternate mechanism for patients, who lack satisfactory therapeutic alternatives and cannot participate in a neladalkib clinical trial, to access investigational neladalkib.
